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Aloe vera is an herbaceous and perennial plant that belongs to the Liliaceae family and used for many medicinal purposes. The present study aimed to systematically review clinical trials regarding the effect of Aloe vera on the prevention and healing of skin wounds.


To identify all related published studies, we searched SID, IRANDOC, Google Scholar, PubMed, MEDLINE, Scopus, Cochrane Library, and ScienceDirect databases in both the English and Persian languages from 1990 to 2016. The keywords used were Aloe vera, wound healing, and prevention. All clinical trials using Aloe vera gel, cream, or derivatives that included a control group with placebo or comparison with other treatments were included in the study. The PRISMA checklist (2009) was used to conduct the review.

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In total, 23 trials that met the inclusion criteria were studied. The results of the studies showed that Aloe vera has been used to prevent skin ulcers and to treat burn wounds, postoperative wounds, cracked nipples, genital herpes, psoriasis, and chronic wounds including pressure ulcers.


Considering the properties of Aloe vera and its compounds, it can be used to retain skin moisture and integrity and to prevent ulcers. It seems that the application of Aloe vera, as a complementary treatment along with current methods, can improve wound healing and promote the health of society.

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  1. Dat AD, Poon F, Pham KB, Doust J. Aloe vera for treating acute and chronic wounds. Cochrane Database Syst Rev. 2012:CD008762. doi: 10.1002/14651858.CD008762.pub2. – DOI – PubMed
  2. Reddy CU, Reddy KS, Reddy JJ. Aloe vera-A wound healer. Asian Journal of Oral Health & Allied Sciences-Volume. 2011;1:91–2.
  3. Shelton RM, Aloe vera. Its chemical and therapeutic properties. Int J Dermatol. 1991;30:679–83. doi: 10.1111/j.1365-4362.1991.tb02607.x. – DOI – PubMed
  4. Malek Hosseini A, Ghaffarzadegan R, Alizadeh SA, Ghaffarzadegan R, Haji Agaei R, Ahmadlou M. Effect of aloe vera gel, compared to 1% silver sulfadiazine cream on second-degree burn wound healing. Complementary Medicine Journal of faculty of Nursing and Midwifery. 2013;3:418–28.
  5. Subramanian S, Kumar DS, Arulselvan P. Wound healing potential of Aloe vera leaf gel studied in experimental rabbits. Asian J Biochem. 2006;1:178–85.
  6. Subramanian S, Kumar DS, Arulselvan P. Wound healing potential of Aloe vera leaf gel studied in experimental rabbits. Asian J Biochem. 2006;1:178–85.
  7. Sahu PK, Giri DD, Singh R, Pandey P, Gupta S, Shrivastava AK, et al. Therapeutic and medicinal uses of Aloe vera: a review. Pharmacol Pharm. 2013;4:599–610. doi: 10.4236/pp.2013.48086. – DOI
  8. Heck E, Head M, Nowak D, Helm P, Baxter C. Aloe vera (gel) cream as a topical treatment for outpatient burns. Burns. 1981;7:291–4. doi: 10.1016/0305-4179(81)90112-1. – DOI
  9. Bunyapraphatsara N, Jirakulchaiwong S, Thirawarapan S, Manonukul J. The efficacy of Aloe vera cream in the treatment of first, second and third degree burns in mice. Phytomedicine. 1996;2:247–51. doi: 10.1016/S0944-7113(96)80050-X. – DOI – PubMed
  10. Somboonwong J, Thanamittramanee S, Jariyapongskul A, Patumraj S. Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. J Med Assoc Thai. 2000;83:417–25. – PubMed
  11. Mosayebi G, Ghazavi A, Aghili B, Mirshafiei A. Immunomodulating activity of Aloe Vera in animal model of multiple sclerosis. Arak Medical University Journal. 2009;12:109–15. Persian.
  12. Boudreau MD, Beland FA. An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006;24:103–54. doi: 10.1080/10590500600614303. – DOI – PubMed
  13. West DP, Zhu YF. Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure. Am J Infect Control. 2003;31:40–2. doi: 10.1067/mic.2003.12. – DOI – PubMed
  14. Shaugh Nessy B. Physicians Desk Reference (PDR) for Herbal Medicine. 2nd ed. New Jersey: Medical Economics Company; 2000.
  15. Moghbel A, Ghalambor A, Allipanah S. Wound healing and toxicity evaluation of Aloe vera cream on outpatients with second degree burns. Iranian Journal of Pharmaceutical Sciences. 2007;3:157–60.
  16. Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C. The efficacy of aloe vera used for burn wound healing: a systematic review. Burns. 2007;33:713–8. doi: 10.1016/j.burns.2006.10.384. – DOI – PubMed
  17. Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J Tradit Complement Med. 2015;5:21–6. doi: 10.1016/j.jtcme.2014.10.006. [ PMC Free Article] – DOI – PMC – PubMed
  18. Joseph B, Raj SJ. Pharmacognostic and phytochemical properties of Aloe vera linn an overview. Int J Pharm Sci Rev Res. 2010;4:106–10. doi: 10.3923/ijp.2011.40.45. – DOI
  19. Schmidt JM, Greenspoon JS. Aloe vera dermal wound gel is associated with a delay in wound healing. Obstet Gynecol. 1991;78:115–7. – PubMed
  20. Khorasani G, Hosseinimehr SJ, Azadbakht M, Zamani A, Mahdavi MR. Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study. Surg Today. 2009;39:587–91. doi: 10.1007/s00595-008-3944-y. – DOI – PubMed
  21. Akhtar MA, Hatwar S. Efficacy of aloe vera extract cream in management of burn wound. J Clin Epidemiol. 1996;49:S24.
  22. Thamlikitkul V, Bunyapraphatsara N, Riewpaiboon W, Theerapong S, Chantrakul C, Thanaveerasuwan T, et al. Clinical trial of aloe vera linn. for treatment of minor burns. Siriraj Med J. 1991;43:313–6.
  23. Molazem Z, Mohseni F, Younesi M, Keshavarzi S. Aloe vera gel and cesarean wound healing; a randomized controlled clinical trial. Glob J Health Sci. 2014;7:203–9. doi: 10.5539/gjhs.v7n1p203. [ PMC Free Article] – DOI – PMC – PubMed
  24. Sabzaligol M, Safari N, Baghcjeghi N, Latifi M, Bekhradi R, Taghizadeh M, et al. The effect of Aloevera gel on prineal pain & wound healing after episiotomy. Complementary Medicine Journal of faculty of Nursing and Midwifery. 2014;4:766–75.
  25. Eghdampour F, Jahdie F, Kheyrkhah M, Taghizadeh M, Naghizadeh S, Haghani H. The effect of aloe vera ointment in wound healing of episiotomy among primiparous women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2013;15:25–31. Persian.
  26. Jahdi F, Kheyrkhah M, Haghani H, Taghizadeh M, Mehrabi E, Eghdampour F. The effect of Aloe Vera ointment on the intensity of perineal pain following episiotomy: A randomized blind clinical trial. Asrar. Journal of Sabzevar School of Medical Sciences . 2011;18:243–9. Persian.
  27. Khorasani G, Ahmadi A, Jalal Hosseinimehr S, Ahmadi A, Taheri A, Fathi H. The Effects of Aloe Vera Cream on Split-thickness Skin Graft Donor Site Management: A Randomized, Blinded, Placebo-controlled Study. Wounds. 2011;23:44–8. – PubMed
  28. Eshghi F, Hosseinimehr SJ, Rahmani N, Khademloo M, Norozi MS, Hojati O. Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study. J Altern Complement Med. 2010;16:647–50. – PubMed
  29. Phillips T, Ongenae K, Kanj L, Slaterfreedberg J. A randomized study of an aloe vera derivative gel dressing versus conventional treatment after shave biopsy excisions. Wounds. 1995;7:200–2.
  30. Alamolhoda SH, Amir Ali Akbari S, Baghban AA, Esmaili S. Effects of Aloe vera gel on breast fissures in breastfeeding women. Pajoohandeh Journal. 2014;19:13–7. Persian.
  31. Tafazoli M, Saeedi R, Gholami Robatsangi M, Mazloom R. Aloevera gel Vs. lanolin ointment in the treatment of nipple sore: a randomized clinical trial. Tehran University Medical Journal. 2010;67:699–704. Persian.
  32. Avijgan M, Kamran A, Abedini A. Effectiveness of Aloe Vera Gel in Chronic Ulcers in Comparison with Conventional Treatments. Iran J Med Sci. 2016;41:S30. [ PMC Free Article] – PMC – PubMed
  33. Panahi Y, Izadi M, Sayyadi N, Rezaee R, Jonaidi-Jafari N, Beiraghdar F, et al. Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds. J Wound Care. 2015;24:459–60, 625. doi: 10.12968/jowc.2015.24.10.459. – DOI – PubMed
  34. Rahmani N, Khademloo M, Vosoughi K, Assadpour S. Effects of Aloe vera cream on chronic anal fissure pain, wound healing and hemorrhaging upon defection: a prospective double blind clinical trial. Eur Rev Med Pharmacol Sci. 2014;18:1078–84. – PubMed
  35. Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J Eur Acad Dermatol Venereol. 2010;24:168–72. doi: 10.1111/j.1468-3083.2009.03377.x. – DOI – PubMed
  36. Thomas DR, Goode PS, LaMaster K, Tennyson T. Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial. Adv Wound Care. 1998;11:273–6. – PubMed
  37. Syed TA, Cheema KM, Ahmad SA, Holt Jr AH. Aloe vera extract 0.5% in hydrophilic cream versus Aloe vera gel for the management of genital herpes in males. A placebo-controlled, double-blind, comparative study. J Eur Acad Dermatol Venereol. 1996;7:294–5.
  38. Syed TA, Ahmad SA, Holt AH, Ahmad SA, Ahmad SH, Afzal M. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study. Trop Med Int Health. 1996;1:505–9. – PubMed
  39. Williams MS, Burk M, Loprinzi CL, Hill M, Schomberg PJ, Nearhood K, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys. 1996;36:345–9. – PubMed
  40. Ghasemi Dehkordi A. Iranian herbal pharmacopeia (in Persian). Vol 1-2. Tehran: Ministry of Health, Treatment and Medical Training publication; 2002. pp. 528–30
  41. Eshgizade M, Basiri Moghaddam M, Mohammadzadeh Moghaddam H, Mahmoudian A, Mesbah M. Comparison of the Effect of Olive Oil, Aloe Vera Extract and Breast Milk on Healing of Breast Fissure in Lactating Mothers: A Randomized Clinical Trial (Clinical Trial Article) Qom Univeresity of Medical Sciences. 2016;10:19–27. Persian.
  42. Vazquez B, Avila G, Segura D, Escalante B. Antiinflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol. 1996;55:69–75. – PubMed