By O.P. Agarwal, M.D., F.I.C.A.
Angiology, Vol 36, Number 8, August 1985
Presented at the 31st Annual Meeting, American College of Angiology and
26th Annual Meeting,International College of Angiology, November 5, 1984.
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Abstract
Five thousand patients of atheromatous heart disease, presented as angina pectoris, were studied over a period of five years. After adding the “Husk of Isabg ol” and “Aloe vera” (an indigenous plant known as ghee-guar-ka-paththa) to the diet, a marked reduction in total serum cholesterol, serum triglycerides, fasting and post parandial blood sugar level in diabetic patients, total lipids and also increase in HDL were noted. Simultaneously the clinical profile of these patients showed reduction in the frequency of anginal attacks and gradually, the drugs, like verapamil, nifedipine, beta-blockers and nitrates, were tapered. The patients, most benefitted, were diabetics (without adding any antidiabetic drug). The exact mechanism of the action of the above two substances is not known, but it appears, that probably they act by their high fibre contents. Both these substances need further evaluation. The most interesting aspect of the study was that no untoward side effect was noted and all the five thousand patients are surviving till date.
Many people also advocate drinking the juice of the aloe vera plant, saying that it can relieve heartburn, alleviate IBS, lower your blood sugar, and a broad range of other claims. (1)
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Introduction
Incidence of atheromatous heart disease is increasing day by day. The factors commonly responsible for atherosclerotic heart disease are diabetes mellitus, hypertension, smoking, family tendency in the form of hyperlipidemias, gout, excessive intake of saturated fatty acids, obesity, lack of exercise, etc.
Heart Disease
Not getting enough physical activity can lead to heart disease—even for people who have no other risk factors. It can also increase the likelihood of developing other heart disease risk factors, including obesity, high blood pressure, high blood cholesterol, and type 2 diabetes. (2)
Promotes heart health: Drinking aloe vera juice could internally help you to improve blood circulation in the body. Aloe vera is known to decrease total fat levels in patients with high cholesterol. This further helps in reducing fatty deposits and blood clots in the arteries of the heart. (3)
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Diabetes
A new study highlights the anti-diabetic effects of aloe vera. The plant, which originates from Africa, has been found to reduce blood sugar levels, which can be helpful for patients suffering from type 2 diabetes.
Diabetes patients could have a reason to take a regular dose of aloe vera, as this succulent plant has been found to keep blood sugar levels in check.
For 6,000 years, aloe or aloe vera plants, which are native to Africa and certain Indian Ocean islands, have been used in phytotherapy, dermatology and cosmetics in the form of gels and creams.
American researchers published this week a review of nine studies exploring the plant’s benefits for type 2 diabetes patients in the “Journal of Alternative and Complementary Medicine.”
According to the various sets of data, taking aloe vera as an oral supplement can significantly reduce the level of glucose in the blood (46.6 mg/dl), as well as reducing HbA1c (1.05%), or glycated hemoglobin, which indicates the average blood glucose level over the previous three months.
Regularly taking aloe vera stimulates the secretion of insulin, which is particularly useful for people suffering from diabetes. Patients with blood sugar levels of 200mg/dl benefitted the most from the effects of aloe vera, the researchers found.
Diabetes is diagnosed when a patient’s fasting blood sugar level is greater than or equal to 130 mg/dl, or when it rises to 200 mg/dl or more one to two hours after a meal. (1)
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Hypertension
Researchers found that consuming up to two ounces of aloe vera juice ($16.5, Aloe Vera Australia) per day could remedy high blood pressure (2)
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For the first time, an Indian plant known as Aloe vera belonging to the Liliacee family along with the Husk of Isabgol, was tried on five thousand patients who had proved ischaemic heart disease due to atherosclerosis and the above two herbal medicines proved to be very effective when mixed with wheat flour paste before preparing the bread. This plant; Aloe vera, is used
in Indian medicine as a tonic, purgative, aphrodisiac, antihelminthic, in various opthalmological disorders, enlargement of spleen, various forms of hepatitis, vomiting, fever due to bronchitis, erysipelas, skin disorders, asthma, leprosy, jaundice, strangury, as a carminative, various musculoskeletal disorders, menstrual suppression and various other nonspecific disorders.
TABLE #1
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TABLE #2
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TABLE #3
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Table #4
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Table #5
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Table #6
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Table #7
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The plant has never been tried in the prevention of atherosclerotic heart disease. The other substance, Husk of Isabgol, in Indian medicine is mainly used to increase the bulk of faeces in constipation. This study is mainly based on its antiatherosclerotic properties.
Materials And Methods
Five thousand patients were selected for the study ranging from 35-65 years of age. (Table I) All patients had clear cut evidence of ischaemic heart disease in the form of unequivocal ECG changes apart from effort angina. (Table II) All patients were subjected to serum chemistry and were screened for fasting blood sugar, post parandial blood sugar (Table III), total serum cholesterol (Table IV), serum triglycerides (Table V), total lipids (Table VI), HDL cholesterol (Table VII), BUN & other investigations were normal.
Out of 5’000 patients, 3167 were diabetics; 2572 patients had a history of smoking 10 to 15 cigarettes per day, for about five years; 2151 patients had evidence of hypertension which was not renal in origin. Out of these 2151 hypertensives, 1360 had mild hypertension and 791 patients had moderate hypertension. The patients, who had unstable angina, past history of myocardial infarction, severe hypertension, severe diabetics & patients on insulin therapy, history of left ventricular failure, gout, were not included in the study. Out of 1065 male non-diabetics, 912 had family history of hyperlipidemia and out of 768 female non diabetic patients, 454 patients were having family history of hyperlipidemia. All 5000 patients were instructed not to consume alcohol in any form during the study. Smoking was also not allowed during study period.
All 5’000 patients were instructed to take 100 gms of fresh flesh gelatin of the plant Aloe vera and 20 gms of Husk of Isabgol mixed with wheat flour to prepare the bread. These breads were consumed at lunch and dinner. Apart from this, the strict dietary schedule and the drugs, which these patients were already taking, in the form of beta blockers, verapamil, nifedipine, isosorbide dinitrate, sulphonylureas, digoxin and diuretics and B-complex, were asked to continue and report weekly. All these patients were assessed clinically and biochemically.
Table #8
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TABLE #9
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TABLE #10
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TABLE #11
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TABLE #12
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TABLE #13
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TABLE #14
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Results
Most of the patients started responding from second week after the therapy was instituted. The improvement was noticed in the form of disappearance of angina pectoris and feeling of well being. The ECG changes also started improving and from 3 months to one year all patients, except 348, had normal tracing even after treadmill (Table VIII).
None of the patients suffered fresh myocardial infarction during the study. The lipid profile also started improving after three months of institution of therapy (Table IX).
Out of 5000 patients, 4652 patients had their normal levels of serum cholesterol ranging from 160 Mgm to 240 Mgm%, serum triglycerides from 50-90 Mgm% (Table X).
Total lipids from 500 Mgm to 800 Mgm% (Table XI), HDL cholesterol ranging from 50 Mgm to 75 Mgm% (Table XII).
Out of 3167 diabetic patients, the blood sugar values, fasting and post parendial, started coming down to normal levels (Table XIII) except in 177 patients, and all the oral hypoglycemic agents had to be withdrawn by the end of two months of therapy. On the contrary, beta blockers, calcium channel blockers, isosorbide dinitrate and diuretics, etc., which the patients were taking for hypertension and angina control, could not be withdrawn completely (Table XIV) but their doses substantially reduced to half of the quantity which they were taking. Similarly the hypertensive patients did not show any significant change in their blood pressure levels. Total number of patients who did not respond to treatment were 525 (348 ischaemic and 177 diabetics out of 5000 patients).
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Discussion
In the present study it has been noticed that the plant had a definite role in the prevention and management of atherosclerotic heart disease. The plant also had a definite role in controlling the blood sugar level in diabetic patients. The exact mechanism of the plant Aloe vera and Husk of Isabgol is not known but it appears that both these substances act by their high fibre contents and these substances need further evaluation. In the entire study no untoward side effect was noticed and all the patients were followed for a period of five years from July 1978 to June 1983 and all the patients turned up for regular follow up and till date all the 5000 patients are surviving. The diabetic patients, except 177 patients, are on diet control alone and none of them has ever complained about any hypoglycemic episode during the study. There is no such study available in medical literature where such a large number (5000 patients) of patients are being followed up for five years and no Indian plant has ever been tried with such success. So this is a unique study of its own type.
To conclude, the Indian plant Aloe vera, when mixed with the Husk of Isabgol, was given to the patients of atherosclerotic heart disease, there was a definite and substantial improvement (about 95%) in their clinical profile apart from biochemical changes and ECG tracings. These two substances need further evaluation to find out the exact mechanism of action on atherosclerosis.
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REFERENCES
- https://www.scientificamerican.com/article/what-are-the-benefits-of-drinking-aloe-juice/
- https://www.cdc.gov/chronicdisease/resources/publications/factsheets/physical-activity.htm#:~:text=Not%20getting%20enough%20physical%20activity%20can%20lead%20to%20heart%20disease,cholesterol%2C%20and%20type%202%20diabetes.
- https://www.indiatoday.in/lifestyle/wellness/story/aloe-vera-juice-5-amazing-benefits-of-guzzling-the-humble-health-drink-316590-2016-04-063
- https://www.news18.com/news/lifestyle/aloe-vera-may-have-beneficial-effects-for-diabetics-1264443.html
- https://www.womansworld.com/posts/health/lower-blood-pressure-numbers-137544
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