A Mirshafiey 1B AghilyS NamakiA RazaviA GhazaviP EkhtiariG Mosayebi

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Abstract

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that leads to an inflammatory demyelination, axonal damage, and progressive neurologic disability that affects approximately 2.5 million people worldwide. The aim of the present research was to test the therapeutic effect of Aloe vera in experimental model of MS. All experiments were conducted on C57BL/6 male mice aged 6-8 weeks. To induce the experimental autoimmune encephalomyelitis (EAE), 250 microg of the myelin oligodendrocyte glycoprotein 35-55 peptide emulsified in complete freund’s adjuvant was injected subcutaneously on day 0 over two flank areas. In addition, 200 ng of pertussis toxin in 100 microL phosphate buffered saline was injected intraperitoneally on days 0 and 2. The therapeutic protocol was carried out intragastrically using 120 mg/kg/day Aloe vera from 7 days before to 21 days after EAE induction. The mice were killed 21 days after EAE induction. The brains of mice were removed for histological analysis and their isolated splenocytes were cultured. The results indicated that treatment with Aloe vera caused a significant reduction in severity of the disease in experimental model of MS. Histological analysis showed 3 +/- 2 plaques in Aloe vera-treated mice compared with 5 +/- 1 plaques in control group. The density of mononuclear infiltration in the CNS of Aloe vera-treated mice (500 +/- 200) was significantly less in comparison to 700 +/- 185 cells in control group. Moreover, the serum level of nitric oxide in treatment group was significantly less than control animals. The level of interferon-gamma in cell culture supernatant of treated mice splenocytes was lower than control group, whereas decrease in serum level of interleukin-10 in treatment group was not significant in comparison with control mice. These data indicate that Aloe vera therapy can attenuate the disease progression in experimental model of MS.

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Aloe helps with sclerosis

Thank you to Barb for this news below that could help others in the same predicament.

 

“I have had sclerosis for about 20 years (I am just over 70 yrs old) and have used lots of prescription creams and tablets. I have been using aloe Vera Skin and Hair gel for about 9 months now and it has just about cleared my legs and arms. It is not an instant fix and it took months until I noticed the gel was was beginning to clear my sclerosis without the use of prescription medication. It leaves your skin sticky for about 5 minutes and I use it morning and night it’s worth a try if you have sclerosis 

I have also been using the Aloe Vera massage pain relief treatment on my shoulders and neck on the advice of my doctor. I used to spend a lot of time at the physio for neck pain and using this product morning and night has made my life a little easier with less pain and I am able to do more gardening and less time at the physio Thank you Aloe Vera Aust your product is excellent.” –  Regards Barb

 

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Please look for the products marked SALE – This offer is available only as 1 pack order (directly on the website) however you can also order as many of the other 50% discount products on the website as you like bundled in with the same order.  If you would like a bulk order of more than one of the Aloe Skin / Hair Gel specials then the offer is also open for 30% less so please email your requirements so we will quote you.

aloe vera Skin Hair Gel 125g     

We have 100’s of 5 Star google reviews and website reviews on the Aloe Skin Hair gel Product click here. Here is a recent review below as an example…

“This is the absolute best quality Aloe Vera gel I have ever used and the customer service is sensational. This combined with the Aloe Vera spray & coconut/Aloe Vera moisturizer have rehydrated my skin beautifully”. Thank You, Sarah

Aloe Vera Australia Products. Please click here… Aloe Vera Australia

 

References
  1. Erfani Majd N, Shahraki R, Tabandeh MR, Hosseinifar S.Vet Res Forum. 2022 Mar;13(1):111-119.
  2. Sørnes EØ, Risal A, Manandhar K, Thomas H, Steiner TJ, Linde M. 2021 Apr;41(5):561-581.
  3. Sehitoglu MH, Karaboga I, Kiraz A, Kiraz HA.North Clin Istanb. 2018 Oct 10;6(3):203-209.
  4. Afraei S, D’Aniello A, Sedaghat R, Ekhtiari P, Azizi G, Tabrizian N, Magliozzi L, Aghazadeh Z, Mirshafiey A.J Food Drug Anal. 2017 Jul;25(3):699-708.
  5. Abdollahnejad F, Mosaddegh M, Nasoohi S, Mirnajafi-Zadeh J, Kamalinejad M, Faizi M.Iran J Pharm Res. 2016 Winter;15(1):293-300.